Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.

@article{Bai2011SulfationO2,
  title={Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.},
  author={Qianming Bai and Leyuan Xu and Genta Kakiyama and Melissa Ann Runge-Morris and Phillip B. Hylemon and Lianhua Yin and William M. Pandak and Shunlin Ren},
  journal={Atherosclerosis},
  year={2011},
  volume={214 2},
  pages={350-6}
}
OBJECTIVE 25-Hydroxycholesterol (25HC) and its sulfated metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), regulate certain aspects of lipid metabolism in opposite ways. Hence, the enzyme for the biosynthesis of 25HC3S, oxysterol sulfotransferase (SULT2B1b), may play a crucial role in regulating lipid metabolism. We evaluate the effect of 25HC sulfation on lipid metabolism by overexpressing the gene encoding SULT2B1b in human aortic endothelial cells (HAECs) in culture. METHODS AND RESULTS… CONTINUE READING

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