Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation.

  title={Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation.},
  author={Hansruedi Glatt},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={11 5},
  • Hansruedi Glatt
  • Published 1997 in
    FASEB journal : official publication of the…
Sulfation is a common final step in the biotransformation of xenobiotics and is traditionally associated with inactivation. However, the sulfate group is electron-withdrawing and may be cleaved off heterolytically in some molecules, leading to an electrophilic cation. The stable heterologous expression of sulfotransferases in indicator cells of standard mutagenicity tests has substantially improved the accessibility of this activation pathway. Sulfotransferase-mediated genotoxic effects have… CONTINUE READING