Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization.

@article{Osterbye2001SulfatidePT,
  title={Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization.},
  author={Thomas Osterbye and Karin Damm J{\o}rgensen and Pam Fredman and J{\o}rgen Tranum-Jensen and Alfred Kaas and Jens Jorgen Veilgaard Brange and Jean L. Whittingham and Karsten Buschard},
  journal={Glycobiology},
  year={2001},
  volume={11 6},
  pages={
          473-9
        }
}
Sulfatide is a glycolipid that has been associated with insulin-dependent diabetes mellitus. It is present in the islets of Langerhans and follows the same intracellular route as insulin. However, the role of sulfatide in the beta cell has been unclear. Here we present evidence suggesting that sulfatide promotes the folding of reduced proinsulin, indicating that sulfatide possesses molecular chaperone activity. Sulfatide associates with insulin by binding to the insulin domain A8--A10 and most… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Similar Papers

Loading similar papers…