Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.

@article{Gray2006SulfatedMF,
  title={Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.},
  author={Christopher A. Gray and Simone Possedente De Lira and M{\'a}rcio Lu{\'i}s Andrade Silva and Eli F. Pimenta and Otavio Henrique Thiemann and Glaucius Oliva and Eduardo Hajdu and Raymond J. Andersen and Roberto G. S. Berlinck},
  journal={The Journal of organic chemistry},
  year={2006},
  volume={71 23},
  pages={
          8685-90
        }
}
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 microM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons. 
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