Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.

  title={Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase.},
  author={Christopher A. Gray and Simone Possedente De Lira and M{\'a}rcio Lu{\'i}s Andrade Silva and Eli F. Pimenta and Otavio Henrique Thiemann and Glaucius Oliva and Eduardo Hajdu and Raymond J. Andersen and Roberto G. S. Berlinck},
  journal={The Journal of organic chemistry},
  volume={71 23},
Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 microM. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons. 
Antileishmanial sesquiterpenes from the Brazilian red alga Laurencia dendroidea.
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes:
Callyptide A, a new cytotoxic peptide from the Red Sea marine sponge Callyspongia species
Callyptide A was found to exhibit growth inhibitory activity when tested against different cancer cell lines, and its structure was determined by extensive 1D and 2D NMR studies and high-resolution mass spectral determination.
Proline‐Containing Dipeptides from a Marine Sponge of a Callyspongia Species
A detailed analysis of the chemical constituents of a marine sponge of Callyspongia sp. was performed. A new proline-containing dipeptide, callyspongidipeptide A (cyclo-((S)-Pro-8-hydroxy-(R)-Ile);
A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species
A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2),
Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula.
HPLC-UV-ELSD-MS-guided fractionation of the anti-parasitic extract obtained from the marine sponge Monanchora arbuscula, collected off the southeastern coast of Brazil, led to the isolation of a
The synthesis and bioactivity of the marine macrolide callyspongiolide.
These synthetic endeavours have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase-independent bioactivity, while also contributing to the wider field of macrolide synthesis.
Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data
It is concluded that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus Callyspongia, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant.
Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract.
A methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis and showed a moderate toxicity on macrophages from BALB/c mice.
Report of in vitro antileishmanial properties of Iberian macroalgae
The results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.