Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis.

@article{Mccarty2000SulfatedGA,
  title={Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis.},
  author={Mark F. Mccarty and A L Russell and Maribo Seed},
  journal={Medical hypotheses},
  year={2000},
  volume={54 5},
  pages={
          798-802
        }
}
High-molecular-weight hyaluronic acid (HA) produced by the synovium may function physiologically to aid preservation of cartilage structure and prevent arthritic pain; both the size and concentration of HA in synovial fluid are diminished in osteoarthritis (OA). Glucosamine therapy for OA can be expected to increase synovial HA production by providing rate-limiting substrate. In addition, certain sulfated glycosaminoglycans and polysaccharides - including chondroitin sulfate (CS), dermatan… Expand
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