Sulfated galactofucan from Lobophora variegata: Anticoagulant and anti-inflammatory properties

@article{Medeiros2008SulfatedGF,
  title={Sulfated galactofucan from Lobophora variegata: Anticoagulant and anti-inflammatory properties},
  author={Valquiria Pereira de Medeiros and Karla Cristina Queiroz and Maria Leila Cardoso and Gl{\'o}ria Regina G{\'o}is Monteiro and Fernanda Wanderley de Oliveira and Suely Ferreira Chavante and Luciana Afonso Guimar{\~a}es and Hugo Alexandre Oliveira Rocha and Edda Lisboa Leite},
  journal={Biochemistry (Moscow)},
  year={2008},
  volume={73},
  pages={1018-1024}
}
Sulfated polysaccharides (fucans and fucoidans) from brown algae show several biological activities, including anticoagulant and anti-inflammatory activities. We have extracted a sulfated heterofucan from the brown seaweed Lobophora variegata by proteolytic digestion, followed by acetone fractionation, molecular sieving, and ion-exchange chromatography. Chemical analyses and 13C-NMR and IR spectroscopy showed that this fucoidan is composed of fucose, galactose, and sulfate at molar ratios of 1… CONTINUE READING