Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3).

@article{Dhakal2013SulfateCA,
  title={Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3).},
  author={Kiran Dhakal and Andrea Adamcakova-Dodd and Hans-Joachim Lehmler and Peter S Thorne and Larry W Robertson},
  journal={Chemical research in toxicology},
  year={2013},
  volume={26 6},
  pages={853-5}
}
PCBs are contaminants in the air of older buildings and cities, which raises the concern of inhalation exposure. No reliable biomarker of such exposure is available. We exposed rats to air containing 2 mg/m(3) PCB3 via nose-only inhalation for 2 h, collected urine, and analyzed it by LC/MS. Each rat inhaled an estimated dose of 35 μg PCB3, and excreted 27 ± 2% of it as sulfates within 24 h. Peak excretion occurred within 6 h. PCB sulfates were stable in urine for at least three days at room… CONTINUE READING

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