Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.

@article{Hanson2004SulfatasesSM,
  title={Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.},
  author={Sarah R. Hanson and Michael D Best and Chung Lim Wong},
  journal={Angewandte Chemie},
  year={2004},
  volume={43 43},
  pages={
          5736-63
        }
}
Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating the sulfation states that determine the function of many physiological molecules. Sulfatase substrates range from small cytosolic steroids, such as estrogen sulfate, to complex cell-surface carbohydrates, such as the glycosaminoglycans. The transformation of these molecules has been linked with important cellular functions, including hormone regulation, cellular degradation, and modulation of signaling… CONTINUE READING

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