Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model

@inproceedings{Xu2014Sulfatase1,
  title={Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model},
  author={Gaoya Xu and Weidan Ji and Yinghan Su and Yang Xu and Yan Yan and Shuwen Shen and Xiaoya Li and Bin Sun and Haihua Qian and Lei Chen and Xiaohui Fu and Meng-chao Wu and Changqing Su},
  booktitle={Oncotarget},
  year={2014}
}
The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including the basic fibroblast growth factor (bFGF)-mediated pathway, by desulfating the cell surface heparan sulfate proteoglycans (HSPGs). bFGF could stimulate cell cycle progression and inhibit cell apoptosis, this biological effect can be reversed by hSulf-1. However, molecular mechanisms have not been fully reported. In the current study, by reactivation of… CONTINUE READING
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