Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.
@article{Sarges1976SulfamylureaHA, title={Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.}, author={Reinhard Sarges and Donald E. Kuhla and Hans E. Wiedermann and Dale A. Mayhew}, journal={Journal of medicinal chemistry}, year={1976}, volume={19 5}, pages={ 695-709 } }
Synthetic methods for a series of novel sulfamylurea derivatives have been developed. The hypoglycemic activity of simple 1-piperidinosulfonylureas is greatly enhanced by attaching an acylaminoethyl function in the 4 position of the piperidine ring. Optimum activity is achieved when the acyl radical is 5-chloro-2-methoxybenzoyl, 2-methoxynicotinyl, 5-chloro-2-methoxynicotinyl, 1,2-dihydro-1-methyl-2-ketonicotinyl, 2,3-ethylenedioxybenzoyl, quinoline-8-carbonyl, or 6-chloroquinoline-8-carbonyl…
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