Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.

  title={Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.},
  author={R. Sarges and D. E. Kuhla and H. E. Wiedermann and D. Mayhew},
  journal={Journal of medicinal chemistry},
  volume={19 5},
  • R. Sarges, D. E. Kuhla, +1 author D. Mayhew
  • Published 1976
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Synthetic methods for a series of novel sulfamylurea derivatives have been developed. The hypoglycemic activity of simple 1-piperidinosulfonylureas is greatly enhanced by attaching an acylaminoethyl function in the 4 position of the piperidine ring. Optimum activity is achieved when the acyl radical is 5-chloro-2-methoxybenzoyl, 2-methoxynicotinyl, 5-chloro-2-methoxynicotinyl, 1,2-dihydro-1-methyl-2-ketonicotinyl, 2,3-ethylenedioxybenzoyl, quinoline-8-carbonyl, or 6-chloroquinoline-8-carbonyl… CONTINUE READING
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