Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.

@article{Sarges1976SulfamylureaHA,
  title={Sulfamylurea hypoglycemic agents. 6. High-potency derivatives.},
  author={Reinhard Sarges and Donald E. Kuhla and Hans E. Wiedermann and Dale A. Mayhew},
  journal={Journal of medicinal chemistry},
  year={1976},
  volume={19 5},
  pages={
          695-709
        }
}
Synthetic methods for a series of novel sulfamylurea derivatives have been developed. The hypoglycemic activity of simple 1-piperidinosulfonylureas is greatly enhanced by attaching an acylaminoethyl function in the 4 position of the piperidine ring. Optimum activity is achieved when the acyl radical is 5-chloro-2-methoxybenzoyl, 2-methoxynicotinyl, 5-chloro-2-methoxynicotinyl, 1,2-dihydro-1-methyl-2-ketonicotinyl, 2,3-ethylenedioxybenzoyl, quinoline-8-carbonyl, or 6-chloroquinoline-8-carbonyl… 
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12 Citations

12 Citations

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