Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site.

@article{Korsinczky2004SulfadoxineRI,
  title={Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site.},
  author={Michael Korsinczky and Katja Fischer and Nanhua Chen and Joanne Baker and Karl H. Rieckmann and Qin Cheng},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 6},
  pages={2214-22}
}
Sulfadoxine is predominantly used in combination with pyrimethamine, commonly known as Fansidar, for the treatment of Plasmodium falciparum. This combination is usually less effective against Plasmodium vivax, probably due to the innate refractoriness of parasites to the sulfadoxine component. To investigate this mechanism of resistance by P. vivax to sulfadoxine, we cloned and sequenced the P. vivax dhps (pvdhps) gene. The protein sequence was determined, and three-dimensional homology models… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Allelic VOL

  • T. Triglia, P. Wang, P. F. Sims, J. E. Hyde, A. F. Cowman
  • EMBO J. 17:3807–3815
  • 1998

Similar Papers

Loading similar papers…