Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.

@article{Dorsey2002SulfadoxinepyrimethamineAO,
  title={Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.},
  author={Grant Dorsey and Denise Njama and Moses R. Kamya and Adithya Cattamanchi and Daniel J. Kyabayinze and Sarah G. Staedke and Anne F Gasasira and Philip J. Rosenthal},
  journal={Lancet},
  year={2002},
  volume={360 9350},
  pages={2031-8}
}
BACKGROUND New antimalarial treatments are urgently needed in sub-Saharan Africa. Improved therapies should decrease failure rates in the short term, but their effect on incidence of subsequent episodes of malaria is little studied. We aimed to compare the short-term and long-term effectiveness of three antimalarial regimens in children from Kampala, Uganda. METHODS We randomly allocated healthy children aged 6 months to 5 years to receive 25 mg/kg sulfadoxine and 1.25 mg/kg pyrimethamine… CONTINUE READING