Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration

Abstract

Toxoplasmosis may cause serious problems after organ transplantation. For treatment of active infection, pyrimethamine combined with a sulfonamide is recommended. During oral sulfadiazine therapy, a significant decrease in cyclosporine concentrations was observed in three heart transplant recipients. This interaction has not been reported previously. 
DOI: 10.1007/BF00180742

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@article{Spes1992SulfadiazineTF, title={Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration}, author={Ch. H. Spes and Ch. E. Angermann and H. U. Stempfle and Katharina Wenke and Karl Theisen}, journal={The clinical investigator}, year={1992}, volume={70}, pages={752-754} }