Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.

@article{Rosen2010Sulf2AE,
  title={Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate.},
  author={Steven D. Rosen and Hassan Lemjabbar-Alaoui},
  journal={Expert opinion on therapeutic targets},
  year={2010},
  volume={14 9},
  pages={935-49}
}
IMPORTANCE OF THE FIELD Sulf-1 and Sulf-2 are sulfatases that edit the sulfation status of heparan sulfate proteoglycans (HSPGs) on the outside of cells and regulate a number of critical signaling pathways. The Sulfs are dysregulated in many cancers with Sulf-2 in particular implicated as a driver of carcinogenesis in NSCLC, pancreatic cancer and hepatocellular carcinoma. AREAS COVERED IN THIS REVIEW This review describes the novel activity of the Sulfs in altering the sulfation pattern of… CONTINUE READING