Sulbactam/Ampicillin versus Cefotaxime as Initial Therapy in Serious Soft Tissue, Joint and Bone Infections

  title={Sulbactam/Ampicillin versus Cefotaxime as Initial Therapy in Serious Soft Tissue, Joint and Bone Infections},
  author={L. L{\"o}ffler and Adolf Bauernfeind and Werner Keyl},
SummaryIn an open, randomised comparative study, 23 patients with bone, joint or soft tissue infections were treated with ampicillin 2g plus sulbactam 1g 3 times a day or cefotaxime 2g 3 times a day as an initial 2- week therapy. Monoinfections with Staphylococcus aureus were the most common bone or joint infections. Clinical cure or improvement 2 weeks after the end of therapy was observed in all 13 patients treated with sulbactam/ampicillin and in 7 of the 8 patients evaluated for efficacy… 
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