Suitability of the cynomolgus monkey as an animal model for drug absorption studies of oral dosage forms from the viewpoint of gastrointestinal physiology.

@article{Ikegami2003SuitabilityOT,
  title={Suitability of the cynomolgus monkey as an animal model for drug absorption studies of oral dosage forms from the viewpoint of gastrointestinal physiology.},
  author={Kengo Ikegami and Kozo Tagawa and Shinji Narisawa and Takashi Osawa},
  journal={Biological & pharmaceutical bulletin},
  year={2003},
  volume={26 10},
  pages={1442-7}
}
To determine the usefulness of the monkey as an animal model, which can predict in vivo performance of humans, the major gastrointestinal physiological parameters of this animal were evaluated. The pH of gastric juice collected by a fiberscope from the stomach in fasted cynomolgus monkeys showed a high acidity level, which ranged from 1.2 to 4.3. The gastric emptying time of oral dosage forms (solution, granules and tablets) showed that the larger size dosage forms seemed to be emptied more… CONTINUE READING

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