Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping.

  title={Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping.},
  author={Miriam Annika Vogt and Sabine Chourbaji and Christiane Brandwein and Christof Dormann and Rolf Sprengel and Peter Gass},
  journal={Experimental neurology},
  volume={211 1},
Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute tamoxifen treatment causes behavioral alterations, while the long-term behavioral effects of tamoxifen in mice are so far unknown. Therefore C57BL/6 male mice, a common strain used… CONTINUE READING

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