Suitability of oligopeptides for induction of hormonal imprinting--implications on receptor and hormone evolution.

@article{Csaba1986SuitabilityOO,
  title={Suitability of oligopeptides for induction of hormonal imprinting--implications on receptor and hormone evolution.},
  author={Gy{\"o}rgy Csaba and P{\'e}ter Kov{\'a}cs and O. T{\"o}r{\"o}k and E Bohdaneczky and Sandor Dr Bajusz},
  journal={Bio Systems},
  year={1986},
  volume={19 4},
  pages={
          285-8
        }
}
12 Citations
Role of proline in the imprinting developed by dipeptides — in Tetrahymena Possible role in hormone evolution
The effects of proline and serine dipeptides containing phenylalanine, alanine and leucine on the behaviour of receptors of Tetrahymena were investigated. Only proline-containing dipeptides were able
Influence of imprinting with A and B chains of insulin on binding and functional changes in tetrahymena
TLDR
The fact remains that both component chains of insulin were able to act as potential imprinters, although the A chain was superior to the B chain in this respect throughout, and combined treatment with the A+B chain ultimately induced the formation of a similar binding site as insulin itself.
Dissimilar effects of L and D amino acids on the growth of Tetrahymena
TLDR
The experiments have substantiated the selectivity of the amino acid receptors of Y.pyriformis, and the extraordinary imprinting potential of tyrosine as well, as judged by its influence on the growth rate.
Imprinting Effects of Proline Containing Dipeptides (Proline-Glycine, Proline-Leucine, Proline-Valine and Their Retro Variants) in Tetrahymena. Evolutionary Conclusions
TLDR
The experiments call attention to the sharp differentiating ability of small peptides at a unicellular level, that could have some role in the selection of molecules for hormone formation, during evolution.
A new approach to the molecular evolution of hormones: the receptorial aspect.
  • G. Csaba
  • Biology
    Experientia. Supplementum
  • 1987
TLDR
Hormone formation in the higher organisms sets an example in how the combination or transformation of certain molecules, acting in themselves as hormones at the lower phylogenetic levels, gives rise to higher hormones, as is the case with thyroxine and its precursors.
Evolutionary significance of the hormone recognition capacity in unicellular organisms. Development of hormone receptors.
  • G. Csaba
  • Biology
    Progress in molecular and subcellular biology
  • 1996
Protozoa live in water, where they are surrounded by a mass of molecules that affect their life. Among these molecules, food molecules are considered as useful, yet some others are noxious or toxic.
Hormonal Imprinting: The First Cellular-level Evidence of Epigenetic Inheritance and its Present State
TLDR
Although the perinatal period is the most critical for faulty imprinting, there are other critical periods as weaning and adolescence, when the original imprinting can be modified or new imprintings develop.
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References

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PHYLOGENY AND ONTOGENY OF HORMONE RECEPTORS: THE SELECTION THEORY OF RECEPTOR FORMATION AND HORMONAL IMPRINTING
  • G. Csaba
  • Biology
    Biological reviews of the Cambridge Philosophical Society
  • 1980
TLDR
Phylogenetic aspects of membrane receptors, selection or reinforcement of receptors in the course of phylogenesis, and selection or amplification of receptors during ontogenesis are studied.
Hormonal imprinting in cell culture I. Impact of a single exposure to insulin on cellular insulin binding capacity in permanent cell lines.
TLDR
Three permanent cell lines showed a durable change in cellular insulin binding capacity in response to a single exposure to insulin, supporting the implication that although the degree and manner of insulin binding differs between cell lines, the impact of a single Exposure to insulin is durably "felt" by all.
The unicellular Tetrahymena as a model cell for receptor research.
  • G. Csaba
  • Biology
    International review of cytology
  • 1985
Insulin binding sites on rat liver nuclear membranes: Biochemical and immunofluorescent studies
TLDR
In contrast to findings with plasma membranes the hormone‐receptor complex is very stable and the kinetics of the dissociation of bound [125I]‐insulin do not indicate negative cooperativity of the binding sites.
Structure and Function Relationships among Synthetic Enkephalin Analogues
TLDR
The discovery of Met- and Leu-enkephalin, the two brain peptides, demonstrated first the existence of hypothetical endogenous substances that can interact with morphine (or opiate) receptors, the so-called endorphins, and also other opioid peptides derivable from β-LPH, which was shown to possess morphinelike activity.
Ontogeny and phylogeny of hormone receptors.
  • G. Csaba
  • Biology
    Monographs in developmental biology
  • 1981
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