Suicides and Suicide Attempts during Long-Term Treatment with Antidepressants: A Meta-Analysis of 29 Placebo-Controlled Studies Including 6,934 Patients with Major Depressive Disorder
@article{Braun2016SuicidesAS, title={Suicides and Suicide Attempts during Long-Term Treatment with Antidepressants: A Meta-Analysis of 29 Placebo-Controlled Studies Including 6,934 Patients with Major Depressive Disorder}, author={Cora Braun and Tom Bschor and Jeremy Franklin and Christopher Baethge}, journal={Psychotherapy and Psychosomatics}, year={2016}, volume={85}, pages={171 - 179} }
Background: It is unclear whether antidepressants can prevent suicides or suicide attempts, particularly during long-term use. Methods: We carried out a comprehensive review of long-term studies of antidepressants (relapse prevention). Sources were obtained from 5 review articles and by searches of MEDLINE, PubMed Central and a hand search of bibliographies. We meta-analyzed placebo-controlled antidepressant RCTs of at least 3 months' duration and calculated suicide and suicide attempt…Â
57 Citations
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References
SHOWING 1-10 OF 76 REFERENCES
Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration database.
- Psychology, MedicineArchives of general psychiatry
- 2000
Assessment of suicides, suicide attempts, and depressive symptom reduction in studies of 7 new antidepressants using the Food and Drug Administration database may help inform discussions about the use of placebo in antidepressant clinical trials.
Suicide in 406 Mood-Disorder Patients With and Without Long-Term Medication: A 40 to 44 Years' Follow-Up
- Psychology, MedicineArchives of suicide research : official journal of the International Academy for Suicide Research
- 2005
ABSTRACT There is no data on the variation in the suicide risk over lifetime and on the suicide-preventive effect of the long-term treatment of mood-disorder patients with antidepressants and…
Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review
- Psychology, MedicineBMJ : British Medical Journal
- 2005
No evidence that SSRIs increased the risk of suicide is found, but important protective or hazardous effects cannot be excluded, and larger trials with longer follow up are required to assess the balance of risks and benefits fully.
Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: a replication analysis of the Food and Drug Administration Database.
- Psychology, MedicineThe international journal of neuropsychopharmacology
- 2001
Suicide risk and symptom reduction among placebo-treated patients participating in antidepressant clinical trials for two recently approved antidepressants, venlafaxine ER and citalopram, which were unavailable during the previous study are assessed.
Suicide Rates in Short-term Randomized Controlled Trials of Newer Antidepressants
- Psychology, MedicineJournal of clinical psychopharmacology
- 2006
Neither use of placebo nor of antidepressants in short-term RCTs was associated with an increased risk of completed suicide among patients with MDD or various anxiety disorders.
Suicide risk in placebo-controlled studies of major depression.
- Medicine, PsychologyThe American journal of psychiatry
- 2001
Fear of increased risk of attempted suicide in the placebo groups should not be an argument against performing short-term and long-term, placebo-controlled trials in major depression.
Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports.
- Psychology, MedicineThe American journal of psychiatry
- 2003
Findings fail to support either an overall difference in suicide risk between antidepressant- and placebo-treated depressed subjects in controlled trials or a difference between SSRIs and either other types of antidepressants or placebo.
Meta-analysis of efficacy and treatment-emergent suicidality in adults by psychiatric indication and age subgroup following initiation of paroxetine therapy: a complete set of randomized placebo-controlled trials.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2011
Overall suicidality incidence was similar between paroxetine and placebo, but in patients with major depressive disorder (MDD), a higher frequency of suicidal behavior occurred with paroxete in MDD, which was largely explained by the higher incidence in young adults.
Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration
- Psychology, MedicineBMJ : British Medical Journal
- 2009
The net effect seems to be neutral on suicidal behaviour but possibly protective for suicidal ideation in adults aged 25-64 and to reduce the risk of both suicidality and suicidal behaviour in those aged ≥65.
Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials.
- Psychology, MedicineBMJ
- 2005
The authors' systematic review, which included a total of 87 650 patients, documented an association between suicide attempts and the use of SSRIs.