Suicide-gene-transduced T-cells for the regulation of the graft-versus-leukemia effect.

  title={Suicide-gene-transduced T-cells for the regulation of the graft-versus-leukemia effect.},
  author={Chiara Bonini and Fabio Ciceri and Sarah Marktel and Claudio Bordignon},
  journal={Vox sanguinis},
  volume={74 Suppl 2},
In allogeneic marrow transplantation (BMT), donor lymphocytes play a central therapeutic role in both graft-versus-leukemia and immune reconstitution. However, their use is limited by the risk of severe graft-vs-host disease (GvHD). Different strategies have been investigated to obtain all the benefits derived from donor lymphocytes while avoiding the risk of GvHD. In the first pilot study, infusions of donor lymphocytes transduced with the Herpes Simplex virus thymidine kinase (HSV-tk) suicide… CONTINUE READING
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