Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.

@article{Bondanza2006SuicideGT,
  title={Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.},
  author={Attilio Bondanza and Veronica Valtolina and Zulma Magnani and Maurilio Ponzoni and Katharina Fleischhauer and Mark Bonyhadi and Catia Traversari and Francesca Sanvito and Salvatore Toma and Marina Radrizzani and Simona La Seta-Catamancio and Fabio Ciceri and Claudio Bordignon and Chiara Bonini},
  journal={Blood},
  year={2006},
  volume={107 5},
  pages={1828-36}
}
In allogeneic hematopoietic cell transplantation (allo-HCT), the immune recognition of host antigens by donor T lymphocytes leads to a beneficial graft-versus-leukemia (GvL) effect as well as to life-threatening graft-versus-host disease (GvHD). Genetic modification of T lymphocytes with a retroviral vector (RV) expressing the herpes simplex virus-thymidine kinase (TK) suicide gene confers selective sensitivity to the prodrug ganciclovir (GCV). In patients, the infusion of TK+ lymphocytes and… CONTINUE READING