Suicide attempts with mirtazapine overdose without complications

@article{Holzbach1998SuicideAW,
  title={Suicide attempts with mirtazapine overdose without complications},
  author={R. Holzbach and H. Jahn and F. Pajonk and Christiane M{\"a}hne},
  journal={Biological Psychiatry},
  year={1998},
  volume={44},
  pages={925-926}
}
BACKGROUND One important aim of pharmacotherapy in depressed patients is the prevention of suicide attempts. Therefore, the medication given should be efficient and safe in overdose. RESULTS We saw two patients after they had overdosed with mirtazapine because of suicidal intention. Both patients had taken 30 and 50 times a normal daily dose and achieved a full recovery without any complications or harm. CONCLUSIONS Mirtazapine seems to be a safe compound in overdose. Therefore, it is an… Expand
Mirtazapine overdose with benign outcome
TLDR
In accordance with previous reports, MTZ seems to be a safe drug in overdose, at least when there is no multiple drug involvement, however, long-term systematic surveillance is needed before drawing any firm conclusion on this issue. Expand
Mirtazapine: a review of its use in major depression.
TLDR
Mirtazapine is effective and well tolerated for the treatment of patients with moderate to severe major depression and the low potential for interaction with drugs that are metabolised by CYP2D6, including antipsychotics, tricyclic antidepressants and some SSRIs, may make mirtazAPine an important option for the Treatment of major depression in patients who require polytherapy. Expand
Mirtazapine overdose is unlikely to cause major toxicity
TLDR
Mirtazapine appears to be relatively benign in overdose, associated with tachycardia, mild hypertension and mild CNS depression not requiring intervention. Expand
Lack of significant toxicity after mirtazapine overdose: A five-year review of cases admitted to a regional toxicology unit
TLDR
A retrospective case analysis of patients admitted to the Toxicology Unit of the Royal Infirmary of Edinburgh between January 2000 and December 2004 after stated mirtazapine overdose found that mirtazerpine overdose appears to be associated with fewer features of severe toxicity than previously reported for other antidepressants. Expand
Treatment of Patients with Dual Diagnosis
  • K. McNamara
  • Psychology, Medicine
  • The Australian and New Zealand journal of psychiatry
  • 2003
TLDR
Kevin McNamara , Consultant Psychiatrist, Palm Beach Currumbin Clinic, Queensland, Australia: I felt compelled to answer MacQueen’s letter and feel that MacQueen has basically missed the point in issuing his challenge to psychiatrists as individuals. Expand
‘Atypical’ Antidepressants in Overdose
TLDR
There can be no generic response by medical practitioners as to the ‘safety’ of these new antidepressants, and the available information is reviewed in a manner intended to benefit both prescribers and clinical toxicologists. Expand
A systematic review of the serotonergic effects of mirtazapine in humans: implications for its dual action status
  • P. Gillman
  • Medicine, Psychology
  • Human psychopharmacology
  • 2006
TLDR
Mirtazapine has no demonstrable serotonergic effects in humans and there is insufficient evidence to designate it as a dual‐action drug, which leads to an emphasis on ST as an important line of evidence. Expand
Inter- and Intraindividual Pharmacokinetic Variations of Mirtazapine and Its N-Demethyl Metabolite in Patients Treated for Major Depressive Disorder: A 6-Month Therapeutic Drug Monitoring Study
TLDR
Continued efforts are warranted to perform PK studies in a natural clinical setting to learn and understand inter- and intraindividual PK variances in real patients treated for longer periods of time. Expand
Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning.
TLDR
The concentration determined in a brain sample suggests a contribution of the metabolite to the drug's pharmacodynamic activity, and significant adverse or synergistic effects among the drugs detected as well as adverse reactions such as a serotonin reaction appeared less probable. Expand
Determination of mirtazapine and its demethyl metabolite in plasma by high-performance liquid chromatography with ultraviolet detection. Application to management of acute intoxication.
TLDR
A specific and accurate RP-HPLC assay was developed for the simultaneous plasma determination of mirtazapine, a new centrally acting noradrenergic and specific serotonin antidepressant, with an active demethyl metabolite. Expand
...
1
2
3
...

References

SHOWING 1-8 OF 8 REFERENCES
Risk of suicide in depression and its implication for psychopharmacological treatment
TLDR
It seems likely that antidepressants with a predominantly serotonergic mechanism of action may be of particular benefit in patients with suicidal problems, which is in line with neurobiological theories about suicidal behaviour and makes them an attractive choice for treatment of depressed patients who are at risk for suicide. Expand
Safety in overdose of mirtazapine: a case report.
TLDR
Mirtazapine: an antidepressant with selective alpha-2 adrenoceptor antagonist effects and its pharmacology and therapeutic potential in the management in major depression. Expand
First report of mirtazapine overdose.
This report describes what is thought to be the first case of mirtazapine overdose occurring since the introduction of the antidepressant drug (Remeron) in the Netherlands in 1994. It is suggestedExpand
Mirtazapine : A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression.
TLDR
Preliminary data indicate that mirtazapine, with its novel mechanism of action, is a promising addition to currently available options for the treatment of depression. Expand
Bioavailability of mirtazapine from Remeron® tablets after single and multiple oral dosing
The absolute bioavailability of mirtazapine, the active constituent of Remeron® tablets, a new antidepressant developed under the laboratory code Org 3770, was assessed in eight healthy young maleExpand
Pharmacokinetic dose‐proportionality study at steady state of mirtazapine from Remeron® tablets
Steady‐state dose proportionality of mirtazapine, the active constituent of Remeron® tablets, a new antidepressant developed under the laboratory code Org 3770, was investigated. Each of 27 youngExpand
Evaluation of the development of acute tolerance to the psychomotor effects of midazolam following intravenous infusions in healthy volunteers
TLDR
Tolerance develops acutely to the effects of midazolam and suggest that tolerance is dependent on both the time and extent of exposure. Expand
Therapie psychiatrischer Erkrankungen