Suicide and Fratricide in Bacterial Biofilms

@article{Thomas2009SuicideAF,
  title={Suicide and Fratricide in Bacterial Biofilms},
  author={Vinai Chittezham Thomas and Lynn E. Hancock},
  journal={The International Journal of Artificial Organs},
  year={2009},
  volume={32},
  pages={537 - 544}
}
  • V. Thomas, L. Hancock
  • Published 1 September 2009
  • Biology, Medicine
  • The International Journal of Artificial Organs
Bacterial autolysis has recently been identified as a key mechanism that regulates different phases of biofilm development including microcolony formation and dispersal. However such autolytic measures are limited to a subfraction of cells within the entire biofilm population. Here we speculate on the role biofilm heterogeneity plays in limiting autolysis within biofilms and further describe the molecular regulation of suicidal and fratricidal mechanisms in biofilm development of Staphylococcus… 

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References

SHOWING 1-10 OF 76 REFERENCES
Bacterial biofilms: prokaryotic adventures in multicellularity.
Bacterial biofilms: a common cause of persistent infections.
TLDR
Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Bacterial resistance to antibiotics: the role of biofilms.
  • B. Hoyle, J. Costerton
  • Medicine, Biology
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1991
Bacteria adhere to natural and synthetic, medically important surfaces within an extracellular polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced antibiotic
Regulation of Autolysis-Dependent Extracellular DNA Release by Enterococcus faecalis Extracellular Proteases Influences Biofilm Development
TLDR
It is shown that both gelatinase (GelE) and serine protease (SprE) contribute to biofilm formation by E. faecalis and provide clues to how the activity of these proteases governs this developmental process, suggesting the interplay of two secreted and coregulated proteases is responsible for regulating autolysis and the release of high-molecular-weight eDNA.
The Enterococcus faecalis fsr Two-Component System Controls Biofilm Development through Production of Gelatinase
TLDR
Inactivation of the fsr-controlled gene gelE encoding the zinc-metalloprotease gelatinase was found to prevent biofilm formation, suggesting that this enzyme may present a unique target for therapeutic intervention in enterococcal endocarditis.
The biological role of death and lysis in biofilm development
  • K. Bayles
  • Biology
    Nature Reviews Microbiology
  • 2007
TLDR
A functional comparison between bacterial programmed cell death and apoptosis is provided and the hypothesis that the differential regulation of these processes during biofilm development contributes to the antibiotic tolerance of biofilm cells is explored.
Extracellular DNA required for bacterial biofilm formation.
TLDR
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface that have inherent resistance to antibiotics and host immune attack.
Survival strategies of infectious biofilms.
Is there a role for quorum sensing signals in bacterial biofilms?
Quorum sensing and microbial biofilms.
TLDR
This chapter will review the role quorum sensing plays in biofilm formation for different species, and different aspects of quorumensing in the context of multispecies biofilms will be discussed.
...
...