Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial

@article{Perroud2009SuicidalID,
  title={Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial},
  author={Nader Perroud and Rudolf Uher and Andrej Maru{\vs}i{\vc} and Marcella Rietschel and O Mors and Neven Henigsberg and Joanna Hauser and Wolfgang Maier and Daniel Souery and Anna Placentino and Aleksandra Szczepankiewicz and Lisbeth J{\o}rgensen and Jana Strohmaier and Astrid W. Zobel and Caterina Giovannini and Amanda Elkin and Cerisse Gunasinghe and Joanna Gray and Desmond Dedalus Campbell and Bhanu Gupta and Anne Farmer and Peter McGuffin and Katherine J Aitchison},
  journal={BMC Medicine},
  year={2009},
  volume={7},
  pages={60 - 60}
}
BackgroundSuicidal thoughts and behaviours during antidepressant treatment, especially during the first weeks of treatment, have prompted warnings by regulatory bodies. The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment.MethodsIn a multicentre part-randomised open-label study, 811 adult patients with moderate to severe unipolar depression were… CONTINUE READING

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