Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia.

@article{Mahmud2013SuicidalED,
  title={Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia.},
  author={Hasan Mahmud and Willem P. T. Ruifrok and B. Daan Westenbrink and Megan V. Cannon and Inge Vreeswijk-Baudoin and Wiek H van Gilst and Herman H W Sillj{\'e} and Rudolf A de Boer},
  journal={Cardiovascular research},
  year={2013},
  volume={98 1},
  pages={37-46}
}
AIMS Suicidal death of erythrocytes (eryptosis) is characterized by cell shrinkage and exposure of phosphatidylserine (PS) residues at the cell surface. Excessive eryptosis may lead to anaemia. We aimed to study the role of eryptosis in heart failure (HF)-associated anaemia. METHODS AND RESULTS We measured eryptosis in rodent models of HF. Typical measures of eryptosis including PS-exposure, increased intracellular Ca(2+) levels, and decreased cell volume were determined by flow cytometry… CONTINUE READING

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