Suggestive linkage of the parathyroid receptor type 1 to osteoporosis.

  title={Suggestive linkage of the parathyroid receptor type 1 to osteoporosis.},
  author={Emma L. Duncan and Matthew A Brown and Janet Sinsheimer and Justin S. Bell and Andrew Carr and Bryan Paul Wordsworth and John A.H. Wass},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={14 12},
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by linkage studies in families of probands with osteoporosis (lumbar spine [LS] or femoral neck [FN] BMD T score < -2.5) and low BMD relative to an age- and gender-matched cohort (Z score < -2.0). One hundred and fifteen probands (35 male, 80 female) and 499 of their first- or second-degree relatives (223 males and 276 females) were recruited for the study. BMD was measured at the LS and FN using… CONTINUE READING
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