Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families.

@article{Evans2008SuggestiveLO,
  title={Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families.},
  author={Lynn M. Evans and Hagop Souren Akiskal and Tiffany A. Greenwood and Caroline M Nievergelt and Paul E. Keck and Susan L McElroy and AdeleD. Sadovnick and Ronald A. Remick and Nicholas J. Schork and John R Kelsoe},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2008},
  volume={147 3},
  pages={
          326-32
        }
}
Attempts to identify bipolar disorder (BP) genes have only enjoyed limited success. One potential cause for this problem is that the traditional categorical BP phenotypes currently used in genetic linkage studies are not the most informative, efficient, or biologically relevant. An alternative to these strict categorical BP phenotypes is quantitative BP phenotypes. By isolating one aspect of a complex trait such as BP into a simple, intermediate, quantitative trait, genes that contribute to the… CONTINUE READING
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