Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

@inproceedings{Solaas2010SuggestiveEO,
  title={Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)},
  author={Karianne Solaas and Vanessa Legry and Kjetil Retterstol and Paul R. Berg and Kirsten Bj\orklund Holven and Jean Ferri{\`e}res and Philippe Amouyel and Sigbj\orn Lien and Javier Romeo and Jara Valtue{\~n}a and Kurt Widhalm and Jonatan R. Ruiz and Jean Dallongeville and Serena Tonstad and Helge Rootwelt and Bente Halvorsen and Marit S. Nenseter and K{\aa}re Inge Birkeland and Per Medb\oe Thorsby and Aline Meirhaeghe and Hilde Irene Nebb},
  booktitle={BMC Medical Genetics},
  year={2010}
}
The liver X receptors (LXR) α and β regulate lipid and carbohydrate homeostasis and inflammation. Lxrβ -/- mice are glucose intolerant and at the same time lean. We aimed to assess the associations between single nucleotide polymorphisms (SNPs) in LXRβ and risk of type 2 diabetes mellitus (T2DM), obesity and related traits in 3 separate cohort studies. Twenty LXRβ SNPs were identified by sequencing and genotyped in the HUNT2 adult nested case-control study for T2DM (n = 835 cases/1986 controls… CONTINUE READING