Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study.

@article{Gonzalez2013SuggestiveEF,
  title={Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study.},
  author={Suzanne D. Gonzalez and Chun Xu and Mercedes E. Ramirez and Juan M. Zavala and Regina Armas and Salvador A. Contreras and Javier Contreras and Albana M Dassori and Robin J. Leach and Deborah Lynne Flores and Alvaro Jerez and Henriette Ravent{\'o}s and Alfonso Ontiveros and Humberto Nicolini and Michael Escamilla},
  journal={Bipolar disorders},
  year={2013},
  volume={15 2},
  pages={
          206-14
        }
}
OBJECTIVES   Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) in European and European-American cohorts. We performed a family-based association study to determine whether CACNA1C is associated with BP in the Latino population. METHODS   This study included 913 individuals from 215 Latino pedigrees recruited from… CONTINUE READING

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