Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.

@article{Nyberg1999SuggestedME,
  title={Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.},
  author={Svante Nyberg and Bo Eriksson and Gabriella Oxenstierna and Christer Halldin and Lars Farde},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 6},
  pages={869-75}
}
OBJECTIVE Multicenter trials with the novel antipsychotic risperidone have suggested a standard dose of 6 mg/day. However, a dose producing the highest response rate in fixed-dose studies is likely to exceed the minimal effective dose in most patients. The aim of this positron emission tomography (PET) study was to suggest a minimal effective dose of risperidone based on measurements of dopamine D2 and serotonin 5-HT2A receptor occupancy. METHOD Eight first-episode or drug-free schizophrenic… CONTINUE READING
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