Suggested mechanism for the formation of 15-hydroxyeicosatrienoic acid by rat epidermal microsomes.

Abstract

We have previously demonstrated that rat epidermal microsomes NADPH-dependently convert 15(S)-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) into 15-hydroxy-5,8,11-eicosatrienoic acid (15-HETrE). The present study examines the mechanism of this reductive conversion. Rat epidermal microsomes were incubated with [1-14C]15-HPETE in the presence and… (More)

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@article{Wauwe1992SuggestedMF, title={Suggested mechanism for the formation of 15-hydroxyeicosatrienoic acid by rat epidermal microsomes.}, author={Jean P Van Wauwe and Martine Coene and G Van Nyen and Wim Cools and L{\'e}onard Le Jeune and W. F. J. Lauwers}, journal={Eicosanoids}, year={1992}, volume={5 3-4}, pages={141-6} }