Sugars and polyols inhibit fibrillogenesis of type I collagen by disrupting hydrogen-bonded water bridges between the helices.

@article{Kuznetsova1998SugarsAP,
  title={Sugars and polyols inhibit fibrillogenesis of type I collagen by disrupting hydrogen-bonded water bridges between the helices.},
  author={Natalia V. Kuznetsova and S. L. Chi and Sergey Leikin},
  journal={Biochemistry},
  year={1998},
  volume={37 34},
  pages={11888-95}
}
To better understand the mechanism of collagen fibrillogenesis, we studied how various sugars and polyols affect the formation and stability of collagen fibers. We combined traditional fiber assembly assays with direct measurement of the interaction between collagen triple helices in fibers by osmotic stress and X-ray diffraction. We found that the effects… CONTINUE READING