Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice

@inproceedings{Glendinning2015SugarinducedCI,
  title={Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice},
  author={John I Glendinning and Sarah M. Stano and Marlena M. Holter and Tali Azenkot and Olivia Q. Goldman and Robert F Margolskee and Joseph R. Vasselli and Anthony Sclafani},
  booktitle={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015}
}
Sensory stimulation from foods elicits cephalic phase responses, which facilitate digestion and nutrient assimilation. One such response, cephalic-phase insulin release (CPIR), enhances glucose tolerance. Little is known about the chemosensory mechanisms that activate CPIR. We studied the contribution of the sweet taste receptor (T1r2+T1r3) to sugar-induced CPIR in C57BL/6 (B6) and T1r3 knockout (KO) mice. First, we measured insulin release and glucose tolerance following oral (i.e., normal… CONTINUE READING

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