Sugar-free, glycine-stabilized intravenous immunoglobulin prevents skin but not renal disease in the MRL/lpr mouse model of systemic lupus

@article{Rcz2010SugarfreeGI,
  title={Sugar-free, glycine-stabilized intravenous immunoglobulin prevents skin but not renal disease in the MRL/lpr mouse model of systemic lupus},
  author={Zsuzsanna Zs{\'o}fia R{\'a}cz and Enikő Nagy and L{\'a}szl{\'o} Rosivall and J{\'a}nos Szebeni and P{\'e}ter Hamar},
  journal={Lupus},
  year={2010},
  volume={19},
  pages={599 - 612}
}
Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephritis had been accelerated in some patients, thus IVIG use in SLE has been abandoned. The availability of non-sugar-stabilized IVIG raised the possible re-evaluation of IVIG for SLE… 
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Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.
TLDR
Results show that deficiency of the Fn14 receptor significantly improves renal disease in a spontaneous lupus nephritis model through prevention of the direct injurious effects of TWEAK on the filtration barrier and/or modulation of cytokine production by resident kidney cells.
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson’s disease
TLDR
The results fail to support a neurorestorative effect of IVIg on the nigrostriatal system in the MPTP-treated mice and suggest a trend toward a detrimental effect of IIG on the dopaminergic system, which underscores the need to proceed with caution before initiating clinical trials of IVG in PD patients.
Evaluating the Murine Anti-Human Antibody Response and Assessment of General Activity and Cognition after Treatment with Human Intravenous Immunoglobulins in Healthy Adult C57/B6J Mice
TLDR
After weekly administration of 400 μg IVIG in C57/B6J mice for the duration of twelve weeks, there was a significant increase of MAHA response against human IgG, but there was no significant change in basic exploratory behavior, anxiety, and cognition.
The immunopathology of cutaneous lupus erythematosus.
Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models
TLDR
It is demonstrated that the concentrating ability of the kidney may be responsible for species differences in sensitivity to CI-AKI, and histopathology alone is insufficient and functional parameters and molecular biomarkers are needed to closely monitor CI- AKI in rodent experiments.
INGESTIGATION OF SIDE EFFECTS AFTER RENAL GENE THERAPY (RNAi) AND LUPUS NEPHRITIS IVIG THERAPY ON MOUSE MODELS

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