Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect.

@article{Avena2005SugardependentRS,
  title={Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect.},
  author={Nicole M. Avena and Kristin A Long and Bartley G. Hoebel},
  journal={Physiology & behavior},
  year={2005},
  volume={84 3},
  pages={359-62}
}
Studies have shown that intermittent sugar availability (12 h/day) produces signs of dependence in rats, including escalation of intake, mu-opioid and dopamine receptor changes, behavioral and neurochemical indices of withdrawal, and cross-sensitization with amphetamine. "Deprivation-effect" paradigms, whereby abstinence from a substance results in enhanced intake, are often used to measure "craving" for drugs of abuse, such as alcohol. The present study used operant conditioning to investigate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Food addiction and neuroimaging.

Current pharmaceutical design • 2011
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…