Sugar binding induces an outward facing conformation of LacY.


According to x-ray structure, the lactose permease (LacY) is a monomer organized into N- and C-terminal six-helix bundles that form a deep internal cavity open on the cytoplasmic side with a single sugar-binding site at the apex. The periplasmic side of the molecule is closed. During sugar/H(+) symport, a cavity facing the periplasmic side is thought to… (More)


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@article{Smirnova2007SugarBI, title={Sugar binding induces an outward facing conformation of LacY.}, author={Irina Smirnova and Vladimir N Kasho and Jun-yong Choe and Christian Altenbach and Wayne L. Hubbell and H Ronald Kaback}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 42}, pages={16504-9} }