Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia: Are Soft Drinks Hard on the Brain?

  title={Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia: Are Soft Drinks Hard on the Brain?},
  author={Heike Wersching and Hannah Gardener and Ralph L. Sacco},
  volume={48 5},
See related article, p 1139. Although the consumption of sodas has been decreasing in most Western countries during the past 2 decades, sugar-sweetened beverages (SSBs) are the leading sources of added sugars in the US diet and are increasing on a global level.1–3 As measured by the recommendation of the 2015 World Health Organization Guideline on the intake of free sugars, a single can of sugar-sweetened soda contains about the upper limit of the recommended 25 to 50 g per day.4 Moreover… 

Interventions to influence consumption of sugar-sweetened beverages

In conclusion, community-level interventions can influence positive changes in consumption of SSBs in children but not in adolescents or adults; an educational and environmental approach focusing on the promotion of water intake in Mexican children was insufficient to improve consumption patterns of SSB and water.

Letter by Chiu Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study".

There was no increased hazard in the incidences of ischemic stroke or Alzheimer disease for subjects with SSBs consumption compared with those with no SSB consumption, and the authors stratified Framingham Heart Study cohort subjects based on their history of consumption of either ASB or SSB.

Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women’s Health Initiative

Higher intake of ASB was associated with increased risk of stroke, particularly small artery occlusion subtype, coronary heart disease, and all-cause mortality, and although requiring replication, these new findings add to the potentially harmful association of consuming high quantities of AsB with these health outcomes.

Interaction of High-Sugar Diet and History of Stroke with Risk of Cognitive Decline in Older Adults

A high-sugar diet and history of stroke interacted synergically in association with cognitive decline in Older adults, which might provide a reference for management of cognition in older adults.

Public Interest in Cognitive Impairment: An Analysis of the Top 50 Articles on Cognitive Impairment on Altmetric

Using Altmetric, a new web-based set of metrics that analyzes the impact of content on social media platforms, the characteristics of influential research articles on the topic of cognitive impairment in social media were investigated.



Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes

Data from 11 studies comparing SSB intake in the highest to lowest quantiles in relation to risk of metabolic syndrome and type 2 diabetes provide empirical evidence that intake of SSBs should be limited to reduce obesity-related risk of chronic metabolic diseases.

Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men.

Sugar-sweetened beverage consumption is associated with a significantly elevated risk of type 2 diabetes, whereas the association between artificially sweetened beverages and type 2abetes was largely explained by health status, pre-enrollment weight change, dieting, and body mass index.

Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages

The consumption of soft drinks, sweetened-milk beverages and energy from total sweet beverages was associated with higher type 2 diabetes risk independently of adiposity and water or unsweetened tea/coffee appear to be suitable alternatives to SSB for diabetes prevention.

Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose-response meta-analysis of prospective studies.

Findings indicate a positive association between sugar-sweetened soft drink intake and type 2 diabetes risk, attenuated by adjustment for BMI, and the trend was less consistent for artificially sweetened soft drinks.

Sweetened Beverage Consumption, Incident Coronary Heart Disease, and Biomarkers of Risk in Men

Background— Sugar-sweetened beverage consumption is associated with weight gain and risk of type 2 diabetes mellitus. Few studies have tested for a relationship with coronary heart disease (CHD) or

Consumption of added sugars is decreasing in the United States.

Although the consumption of added sugars in the United States decreased between 1999-2000 and 2007-2008, primarily because of a reduction in soda consumption, mean intakes continue to exceed recommended limits.

Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort.

Both SSB consumption and ASB consumption were associated with increased T2D risk, and randomized trials are required to prove a causal link between SSBs and ASBs.

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study

Higher recent and higher cumulative intake of artificially sweetened soft drinks were associated with an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease dementia.

Diet Soft Drink Consumption is Associated with an Increased Risk of Vascular Events in the Northern Manhattan Study

Daily diet soft drink consumption was associated with several vascular risk factors and with an increased risk for vascular events, and this persisted after controlling further for the metabolic syndrome, peripheral vascular disease, diabetes, cardiac disease, hypertension, and hypercholesterolemia.

Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction

Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity, and both artificially sweetened beverage and fruit juice were unlikely to be healthy alternatives to sugarsweetened beverages for the prevention of type 1 diabetes.