Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey.

@article{Boer2006SugammadexAN,
  title={Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey.},
  author={Hans Donald de Boer and Jan van Egmond and Francien M van de Pol and Anton H. Bom and Leo H. D. J. Booij},
  journal={British journal of anaesthesia},
  year={2006},
  volume={96 4},
  pages={473-9}
}
BACKGROUND Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about 90% induced by rocuronium or the non-steroidal neuromuscular blocking drugs, mivacurium or atracurium, in the anaesthetized Rhesus monkey. METHODS After a bolus injection of rocuronium, mivacurium or… CONTINUE READING
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