Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction

@article{Pascoli2015SufficiencyOM,
  title={Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction},
  author={Vincent Pascoli and Jean Terrier and Agn{\`e}s Hiver and Christian L{\"u}scher},
  journal={Neuron},
  year={2015},
  volume={88},
  pages={1054-1066}
}
The factors causing the transition from recreational drug consumption to addiction remain largely unknown. It has not been tested whether dopamine (DA) is sufficient to trigger this process. Here we use optogenetic self-stimulation of DA neurons of the ventral tegmental area (VTA) to selectively mimic the defining commonality of addictive drugs. All mice readily acquired self-stimulation. After weeks of abstinence, cue-induced relapse was observed in parallel with a potentiation of excitatory… CONTINUE READING
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