Sufentanil and alfentanil cause vasorelaxation by mechanisms independent of the endothelium.

@article{Karasawa1993SufentanilAA,
  title={Sufentanil and alfentanil cause vasorelaxation by mechanisms independent of the endothelium.},
  author={Fujio Karasawa and Victor Iwanov and Robert F. W. Moulds},
  journal={Clinical and experimental pharmacology & physiology},
  year={1993},
  volume={20 11},
  pages={
          705-11
        }
}
1. The aim of these experiments was to determine if the vasorelaxation of the rat isolated aorta induced by sufentanil or alfentanil is mediated by the endothelium, and, if not, by alpha-adrenoceptor blockade, or a direct effect on the smooth muscle. 2. Both sufentanil (from 10(-7) mol/L to 10(-4) mol/L) and alfentanil (from 10(-7) mol/L to 3 x 10(-4) mol/L) relaxed rings, where endothelium was intact and precontracted with 40 mmol/L KCl, in a concentration-related manner. Similarly, sufentanil… CONTINUE READING
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