Sudden withdrawal of carbamazepine increases cardiac sympathetic activity in sleep

  title={Sudden withdrawal of carbamazepine increases cardiac sympathetic activity in sleep},
  author={Michael J. Hennessy and Mary Tighe and C. D. Binnie and Lina Nashef},
  pages={1650 - 1654}
Objective: To evaluate the cardiac autonomic effects of abrupt withdrawal of carbamazepine (CBZ) during sleep in patients with epilepsy. Background: The pathophysiology of sudden unexpected death in epilepsy (SUDEP) is uncertain, with ictal or peri-ictal cardiorespiratory compromise appearing probable. Risk factors for SUDEP include multiple antiepileptic drugs (AED), poor compliance, and abrupt AED withdrawal. The spectral analysis of the beat-to-beat heart rate variability (HRV) displays two… 

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