Sudden withdrawal of carbamazepine increases cardiac sympathetic activity in sleep.

@article{Hennessy2001SuddenWO,
  title={Sudden withdrawal of carbamazepine increases cardiac sympathetic activity in sleep.},
  author={Michael J. Hennessy and Miranda Tighe and C. D. Binnie and Lina Nashef},
  journal={Neurology},
  year={2001},
  volume={57 9},
  pages={
          1650-4
        }
}
OBJECTIVE To evaluate the cardiac autonomic effects of abrupt withdrawal of carbamazepine (CBZ) during sleep in patients with epilepsy. BACKGROUND The pathophysiology of sudden unexpected death in epilepsy (SUDEP) is uncertain, with ictal or peri-ictal cardiorespiratory compromise appearing probable. Risk factors for SUDEP include multiple antiepileptic drugs (AED), poor compliance, and abrupt AED withdrawal. The spectral analysis of the beat-to-beat heart rate variability (HRV) displays two… CONTINUE READING

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