Sudden unexpected death of a term fetus in an anticardiolipin-positive mother.

@article{Ottaviani2004SuddenUD,
  title={Sudden unexpected death of a term fetus in an anticardiolipin-positive mother.},
  author={Giulia Ottaviani and Anna Maria Lavezzi and Lino Rossi and Luigi Matturri},
  journal={American journal of perinatology},
  year={2004},
  volume={21 2},
  pages={
          79-83
        }
}
A term male fetus suddenly and unexpectedly died in utero at the 40th week of gestation. The mother had a regular and unremarkable pregnancy except for an anticardiolipin antibodies positivity. The histological examination of the cardiac conduction system showed islands of conduction tissue in the central fibrous body, known as persistent fetal dispersion. The brainstem examination revealed a severe bilateral hypoplasia of the arcuate nucleus. This morphological finding has been described in… 
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References

SHOWING 1-10 OF 17 REFERENCES
Hypoplasia of medullary arcuate nucleus in unexpected late fetal death (stillborn infants): a pathologic study.
TLDR
A high frequency of hypoplasia of the ARCn occurs in fetuses who have died "sine causa," ie, in a similar manner to that observed in sudden infant death syndrome, as well as in stillbirths that had a normal karyotype.
Sudden Infant Death Syndrome (SIDS): a study of cardiac conduction system.
Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women.
TLDR
The prevalence of CCHB in newborns of prospectively followed up women already known to be anti-Ro/SSA positive and with known CTD was 2%.
Brain stem lesions in the sudden infant death syndrome: variability in the hypoplasia of the arcuate nucleus
TLDR
It is hypothesized that infants without the full complement of neurons and neuropil (ARCn hypoplasia) are at risk for SIDS because they are unable to develop appropriate cardioventilatory control during this crucial developmental period.
XVIII. Persistent fetal dispersion of the atrioventricular node and His bundle within the central fibrous body.
TLDR
In the hearts of two victims of sudden unexpected death there was abnormally delayed persistence of the pattern of fetal dispersion of the A-V (atrioventricular) node and His bundle within the central fibrous body, characterized by a splayed or excessively fragmented histological appearance.
Antiphospholipid syndrome and recurrent miscarriages.
Association between Pulmonary Hypoplasia and Hypoplasia of Arcuate Nucleus in Stillbirth
TLDR
It is demonstrated that in about a third of stillbirths there is a congenital hypodevelopment of both lung and arcuate nucleus and in these cases the ARCn hypoplasia would exert a negative effect on respiratory movements in utero and therefore on lung development.
Potter's Pathology of the Fetus and Infant
TLDR
Dr Potter succinctly cataloged some 19 000 fetal and neonatal autopsies from several sources, creating a major work, which as of the third edition comprised a single volume of 28 chapters and nearly 700 pages.
QT interval prolongation in asymptomatic anti-SSA/Ro-positive infants without congenital heart block.
TLDR
Infants born to mothers who carry anti-Ro autoantibodies may show QT interval prolongation and should be monitored with EKG during the first months of life.
Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis.
TLDR
A working definition of pulmonary hypoplasia (PH) was established by retrospective assessment of lung growth both in recognised and hypothetical PH-associated conditions and retrospectively clarified the clinical and radiological findings.
...
1
2
...