Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives.

@article{Semsarian2015SuddenCD,
  title={Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives.},
  author={Christopher Semsarian and Jodie Ingles and Arthur A. M. Wilde},
  journal={European heart journal},
  year={2015},
  volume={36 21},
  pages={
          1290-6
        }
}
The sudden death of a young, apparently fit and healthy person is amongst the most challenging scenarios in clinical medicine. Sudden cardiac death (SCD) is a devastating and tragic outcome of a number of underlying cardiovascular diseases. While coronary artery disease and acute myocardial infarction are the most common causes of SCD in older populations, genetic (inherited) cardiac disorders comprise a substantial proportion of SCD cases aged 40 years and less. This includes the primary… 
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Molecular autopsy in sudden cardiac death – ethical issues and clinical implication for relatives
TLDR
The goal of this review is to summarize the current state of knowledge regarding various genetic causes of sudden cardiac death emphasizing the requisite of post-mortem genetic testing for identifying surviving relatives at risk for future lethal events.
Evaluation After Sudden Death in the Young.
TLDR
The underlying causes of sudden cardiac death in the young are outlined, the universal approach to familial evaluation following a young person's sudden death is outlined and the underlying inherited cardiac condition in the family is outlined.
Update on cardiomyopathies and sudden cardiac death
TLDR
Since SCD can be the first and last clinical presentation of the underlying disease, autopsy could be the only medical examination available for early diagnosis and it should be performed according to guidelines of the Association for European Cardiovascular Pathology.
Sudden arrhythmic death and cardiomyopathies in the young: a molecular and pathology overview
Sudden Arrhythmic Death During Exercise: A Post-Mortem Genetic Analysis
TLDR
A comprehensive analysis of sudden cardiac death-related genes in individuals who died suddenly while exercising enabled the identification of potentially causative variants and helps to identify at-risk relatives.
Autopsy in sudden cardiac deaths
TLDR
This review aims to offergenetical consulting to the family members of the sudden cardiac death cases and clarify the etiology of death via genetical evaluation if the macroscopic, toxicologic and histopathologic examinations fail to explain the cause of the suddenly cardiac death especially in children and young adults.
Sudden unexpected death in the young - Value of massive parallel sequencing in postmortem genetic analyses.
Genetic screening in sudden cardiac death in the young can save future lives
TLDR
Cardiac ion channel genetic testing in autopsy-negative sudden death victims has a high diagnostic yield, with identification of the disease in 40 % of families.
The Advancement of Postmortem Investigations in Sudden Cardiac Death
TLDR
Providing a comprehensive understanding on the advancement of postmortem examination will help improve the minimum standards of routine autopsy practice, develop new guidelines for radiological examination and prevent the growing heterogeneity of the pathologies underlying SCD.
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References

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TLDR
In cases of autopsy-negative SUD, continued investigation through either a cardiologic and genetic evaluation of first- or second-degree relatives or a molecular autopsy may elucidate the underlying mechanism contributing to the sudden death and allow for identification of living family members with the pathogenic substrate that renders them vulnerable.
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TLDR
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TLDR
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TLDR
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TLDR
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