Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.

  title={Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.},
  author={Yosuke Matsuno and Jun Deguchi and Yusuke Hirasawa and Kunio Ohyama and Hiroo Toyoda and Chieko Hirobe and Wiwied Ekasari and Aty Widyawaruyanti and Noor Cholies Zaini and Hiroshi Morita},
  journal={Bioorganic & medicinal chemistry letters},
  volume={18 13},
Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6alpha-acetoxyvouacapane (3) and 6alpha,7beta-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6alpha,7beta-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite… CONTINUE READING