Sucrose fatty acid sulphate esters as novel vaccine adjuvants: effect of the chemical composition.

@article{Blom2004SucroseFA,
  title={Sucrose fatty acid sulphate esters as novel vaccine adjuvants: effect of the chemical composition.},
  author={Anneke G Blom and Luuk A Th Hilgers},
  journal={Vaccine},
  year={2004},
  volume={23 6},
  pages={743-54}
}
Adjuvant activity of novel, synthetic sucrose derivatives towards a recombinant glycoprotein was determined in large, non-rodent animal species. Compared to antigen alone, up to 3000-fold higher virus neutralizing antibody titres (VNTs) and 10-fold higher cellular responses against classical swine fever virus were observed in pigs after two immunizations with the sucrose derivatives combined with a squalane-in-water emulsion. The chemical composition of the derivative was crucial and sucrose… CONTINUE READING
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