Sucralfate protects intestinal epithelial cells from radiation-induced apoptosis in rats.

Abstract

Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following: (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.

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@article{MatsuuMatsuyama2006SucralfatePI, title={Sucralfate protects intestinal epithelial cells from radiation-induced apoptosis in rats.}, author={Mutsumi Matsuu-Matsuyama and Kazuko Shichijo and Kumio Okaichi and Kouji Ishii and Chung Yang Wen and Eiichiro Fukuda and Toshiyuki Nakayama and Masahiro Nakashima and Yutaka Okumura and Ichiro Sekine}, journal={Journal of radiation research}, year={2006}, volume={47 1}, pages={1-8} }