Succinylacetone effects on renal tubular phosphate metabolism: a model for experimental renal Fanconi syndrome.

@article{Roth1991SuccinylacetoneEO,
  title={Succinylacetone effects on renal tubular phosphate metabolism: a model for experimental renal Fanconi syndrome.},
  author={Karl S. Roth and Brian E. Carter and Edmund S Higgins},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1991},
  volume={196 4},
  pages={428-31}
}
Phosphaturia is a prominent component of the renal Fanconi syndrome associated with the autosomal recessive disease, hereditary tyrosinemia. Succinylacetone (SA), the metabolic by-product of the enzyme deficiency, can be shown to produce multiple adverse effects on rat renal epithelial cell function in vitro. With the use of this compound, we have examined… CONTINUE READING