Succinate transport inhibition by valproate in rat renal mitochondria.

  title={Succinate transport inhibition by valproate in rat renal mitochondria.},
  author={Lucien Rumbach and G{\'e}rard Cr{\'e}mel and C A Marescaux and Jean Marie Warter and Albert Waksman},
  journal={European journal of pharmacology},
  volume={164 3},
Sodium valproate is an antiepileptic drug which may have side effects on different organs. Its mechanism of action, as yet unclear, may involve an effect on membranes. One possibility, an effect on mitochondrial membranes via an inhibition of oxidative phosphorylation, has been studied here by observing the transmembranal transport of a respiratory substrate, succinate, in rat kidney mitochondria incubated with valproate, or from rats injected with valproate. Succinate transport was inhibited… CONTINUE READING

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