Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

Abstract

Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ischemia increase succinate blood levels, we investigated the role of this… (More)
DOI: 10.1186/s12964-014-0078-2

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