Succinate Overproduction: A Case Study of Computational Strain Design Using a Comprehensive Escherichia coli Kinetic Model

@inproceedings{Khodayari2014SuccinateOA,
  title={Succinate Overproduction: A Case Study of Computational Strain Design Using a Comprehensive Escherichia coli Kinetic Model},
  author={Ali Khodayari and Anupam Chowdhury and Costas D. Maranas},
  booktitle={Front. Bioeng. Biotechnol.},
  year={2014}
}
Computational strain-design prediction accuracy has been the focus for many recent efforts through the selective integration of kinetic information into metabolic models. In general, kinetic model prediction quality is determined by the range and scope of genetic and/or environmental perturbations used during parameterization. In this effort, we apply the k-OptForce procedure on a kinetic model of E. coli core metabolism constructed using the Ensemble Modeling (EM) method and parameterized… CONTINUE READING

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Succinate overproduction: a case study of computational strain design using a comprehensive Escherichia coli kinetic model

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  • Front. Bioeng. Biotechnol
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